Perfect Vessels & Veins

• Promotes Healthy Microcirculation
• Helps Support Blood Vessel and Cardiovascular Health
• Maintains Optimal Vasomotor and Vascular Tone

CARDIOVASCULAR HEALTH

This product is a powerful blend of botanical extracts shown to promote healthy microcirculation and support vascular strength and tone. The four ingredients in this product works nergistically to support all layers of the blood vessel structure. This product includes troxerutin, diosmin, horse chestnut extract, and gotu kola, which have been extensively researched for their benefits to blood vessel health, improvements in
microcirculation, and the ability to strengthen vascular tone.

Overview
The muscles of blood vessels need to receive constant stimulation to maintain a resting level of contraction. This phenomenon is known as vasomotor tone. The vasomotor tone is, in turn, the result of a complex set of interactions that control both the relaxation and
contraction of blood vessels.

This tone maintains the diameter of blood vessels and plays a vital role in maintaining healthy blood pressure levels within the normal range. The vasomotor tone is also
controlled by the sympathetic nervous system, which releases norepinephrine to stimulate the appropriate response to various hormones and physiologic situations. 

Vasoconstriction, whether due to an increase in venous wall stress or biomechanical stretch, is sufficient to cause an increase in vasomotor tone. Narrowing blood vessels leads to a reduction in blood supply and consequently a reduction in oxygen supply to various organs, making this a critical factor for maintaining optimal
energy and health. 

Furthermore, such changes in vasomotor tone impact cardiac output and may lead to oxygenation and microcirculatory challenges. Recent research proves flavonoids are natural substances that have special circulatory system benefits and support optimal
circulatory function. They also play a key role in microcirculation

and optimal blood flow. Particularly, troxerutin, diosmin, and horse chestnut extract appear to protect blood vessels from oxidative stress and are specifically well-suited to support those with circulatory and venous tone challenges.

Diosmin
Diosmin is derived from the bioflavonoid hesperidin found in citrus rinds. The diosmin used in this product is refined through micronization, which results in minute particles that are significantly smaller in size than standard diosmin. This allows for rapid, efficient delivery to the bloodstream and the inner lining of veins. Micronized purified flavonoid fraction (MPFF) supports vascular health by prolonging the impact norepinephrine has
on the vessel wall, which promotes venous tone. In addition to promoting venous tone, research shows diosmin promotes circulatory health by helping to improve lymphatic drainage and protecting microcirculation.

It has also been shown to maintain normal inflammatory balance and decrease capillary
permeability.

Troxerutin
Troxerutin is a naturally occurring flavonoid that is isolated from tea, coffee, and vegetables. It has a variety of activities, including strong antioxidant capacity and the ability to maintain normal inflammatory balance.

Specifically, troxerutin is able to promote healthy microcirculation and protect endothelial cells from oxidative stress. In a 2015 study, 134 patients received a mixture of
diosmin, troxerutin, and hesperidin for circulatory challenges and this mixture was found to be safe and effective for maintaining healthy venous sufficiency.

Gotu Kola
Gotu kola (Centella asiatica) is a perennial plant found throughout India in moist places up to an altitude of 1800 m, and the whole plant is used for many health benefits.

The primary active constituents of gotu kola are saponins, also called triterpenoids,
which include asiaticosides.

These triterpene saponins are mainly responsible for this plant’s vascular benefits and ability to help with normal tissue repair.

Gotu kola stimulates collagen synthesis and helps improve the tone and elasticity of vascular walls. It has also been shown to improve microcirculation and promote healthy capillary permeability. In addition, gotu kola supports functional parameters of healthy venous structure and hemodynamics.

Horse Chestnut Extract
Horse chestnut extract (Aesculus hippocastanum) is native to Southeastern Europe. Its seed extracts and their concentrates contain phytocompounds, including flavonoids, polyphenols, triterpenoid saponin glycosides (aescin), epicatechin, tannins, kaempferol, esculin, and fraxin, with aescin as the chief bioactive compound.

Aescin gives this herb its ability to promote healthy venous tone normal lymph drainage and favorable blood flow dynamics. It is also beneficial in improving microcirculation, which is the venous network responsible for the circulation of blood from the heart to
the capillaries and back to the heart. Maintaining the structural integrity of capillaries is imperative for the proper functioning of the venous system overall. Research indicates Ruscus extract and horse chestnut seed demonstrate the ability to maintain healthy
venous sufficiency.

Directions
3 capsules per day or as recommended by your health care professional.
Does Not Contain Gluten, yeast, artificial colors, or flavors.

Cautions
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.

Jeffrey Mark, M.D., ABIM, ABAARM, NBPAS | Board Certified in Anti-Aging, Regenerative
and Functional Medicine. Board Certified in Gastroenterology and Internal Medicine

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*